Healthcare Providers: Disease Information
Cryopyrin-Associated Periodic Syndromes (CAPS) are a group of rare, inherited, autoinflammatory diseases. CAPS are made up of 3 subtypes that share some common symptoms, including rash, fever/chills, joint pain, fatigue, and eye redness/pain.
The 3 subtypes of CAPS are Familial Cold Autoinflammatory Syndrome (FCAS), Muckle-Wells Syndrome (MWS), and Neonatal-Onset Multisystem Inflammatory Disease (NOMID). LEARN MORE
FCAS may cause frequent attacks that include symptoms such as rash, fever/chills, joint pain, eye redness/pain, and fatigue. Flares are triggered by exposure to cooling temperatures. Diagnosis usually occurs shortly after birth.
MWS is characterized by recurrent rash, fever/chills, joint pain, eye redness/pain, and fatigue. Symptoms are triggered by random, unknown factors and possibly by stress, exercise, or cold. MWS is often associated with hearing loss and amyloidosis—the presence of a protein in the kidneys or other organs that can interfere with their function.
NOMID, also called Chronic Infantile Neurologic Cutaneous Articular (CINCA) Syndrome, is a rare, congenital, systemic, inflammatory condition distinguished by recurrent fever, joint disease, rash, and significant central nervous system disease. Symptoms generally appear shortly after birth. NOMID is the most severe form of CAPS.